Cd-ISTAb

Nih

Cd-ISTAb is an engineered antibody for treatment of C. difficile infections (CDI).  The strategy is based on a novel technology that uses Infection Site Targeted neutralizing anti-toxin Antibodies (ISTAb). ISTAbs are directed to the site of infection through specific phage-derived cell wall targeting (CWT) domains that bind specific bacterial species.
ISTABs unique properties:

  • Accumulate at the site of infection through binding to the bacteria,
  • Capturing and sequester the toxins as they are released, thereby immediately neutralizing their immune suppressive and tissue destructive effects and prevent toxemia.
  • As the Fc receptor binding sites in the ISTAbs remain intact, ISTAbs mediate opsonophagocytic killing, thus providing a means for concurrent toxin neutralization and bacterial clearance.

Cd-ISTAb is a cocktail of two potent antibodies that neutralize C. difficile Toxin A (TcdA) and TcdB) and are targeted to the surface of bacteria.

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