The ongoing COVID-19 pandemic highlights the need for sensitive diagnostic platforms and novel biomarkers. EBOV soluble glycoprotein (sGP) represents a unique and powerful biomarker for the detection of EBOV infection and EVD prognosis for several reasons. The presence of sGP in the blood prior to, or simultaneously with, PCR-based assays improves the diagnostic window. As previously noted, survival outcomes from EBOV infection depend critically on the initiation of supportive measures, which heavily rely on accurate diagnoses in resource-limited settings. Rapid diagnosis facilitates faster treatment initiation, thereby improving patient outcomes (Chertow et al., 2014Feldmann and Geisbert, 2011Fowler et al., 2014). Quarantine of affected individuals has profound implications in infection and outbreak management and prevention. Alternatively, a confirmation of a negative test allows for healthcare providers to efficiently leverage their resources in treating patients. Because sGP is a protein biomarker, there is flexibility in the assay designs that can be used with the biomarker (e.g., lateral flow assays). The NHP study suggests that levels

IBT and collabortors describe a rapid and sensitive diagnostic for EVD through microring resonator sensors in conjunction with a unique biomarker of EBOV infection, soluble glycoprotein (sGP). Microring resonator sensors detected sGP in under 40 min with a limit of detection (LOD) as low as 1.00 ng/mL in serum. Furthermore, we validated our assay with the detection of sGP in serum from EBOV-infected non-human primates.